Journal: Aging (Albany NY)
Article Title: N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice
doi: 10.18632/aging.100927
Figure Lengend Snippet: Mean (+/−SEM) auditory brainstem response (ABR) thresholds of +/+, +/dwg and dwg/dwg mice at 1, 3, 6 and 9 months of age at ( A ) 8 kHz, ( B ) 16 kHz and ( C ) 32 kHz. ( D ) Mean (+/−SEM) ABR threshold shifts of +/dwg and dwg/dwg mice relative to +/+ mice at 1, 3, 6 and 9 months of age at 8, 16 and 32 kHz (n= 29, 29, 26 and 15 for dwg/dwg mice at 1, 3, 6 and 9 months of age; n = 11, 12, 12, 12 for +/+ mice at 1, 3, 6 and 9 months of age and n = 12, 12, 12 and 12 for +/dwg mice at 1, 3, 6 and 9 months of ages).
Article Snippet: Breeding, genotyping and auditory brainstem response (ABR) hearing tests were conducted at the Jackson Laboratory and the cochleae from these mice were fixed and shipped to the University at Buffalo for histological evaluation.
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